The Poisoned Electrick Head sound could be described as a combination of space rock and angular post-punk, with heavy, distorted guitars and analogue synthesizers providing an idiosyncratic backing to the two lead vocalists' unconventional scattergun delivery. An early review in the 'popular' music magazine NME described them as sounding like "UK Subs playing early Genesis".,and the band drew frequent comparisons to Hawkwind, Devo, and Cardiacs. Many Poisoned Electrick Head tracks also experimented with ambient electronic passages, dropped-in samples and dub techniques.