Description

Psychosis puts a major burden on patients and society. Traditionally, the dopamine hypothesis attempted to explain the pathogenic mechanisms underlying positive symptoms, and the neurodevelopmental hypothesis its origins. More recently cognitive and social models have gained popularity. However, these 4 theories have not been satisfactorily integrated; for example, many cognitive and social models make no mention of dopamine, neurodevelopment, or the brain. Is it possible to integrate these models?

One integrative model suggests that early physical hazards and childhood abuse can operate on those genetically vulnerable to cause the dopamine system to become sensitised and over-reactive. Furthermore, factors like childhood adversity, inner city living, discrimination, and intrusive life events (e.g. bullying, assault) can bias the mindset that individuals use to interpret experiences, towards excessive arousal and suspicion of others. Subsequent stress or drug abuse can result in dysregulated dopamine release, causing the misattribution of importance to innocuous events, which are then misinterpreted by the biased cognitive processes. The resulting paranoia and hallucinations cause further stress, which in turn causes further dopamine release. Sadly, the increasing use of compulsion and the conditions in many UK psychiatric units exacerbate this vicious system.

Robin Murray is Professor of Psychiatric Research at the Institute of Psychiatry, Psychology and Neuroscience, Kings College, and indeed has spent most of his working life there apart from one year at NIMH in the USA. His particular interest is in psychosis. He was one of the first to suggest that schizophrenia was in part a neurodevelopmental disorder, and he and his colleagues have contributed to the understanding that environmental factors such as obstetric events, drug abuse and social adversity dysregulate striatal dopamine and thus increase the risk of psychosis. He also cares for people with psychosis at the South London and Maudsley NHS Trust. He has written over 800 articles, not all of them boring! He is the most frequently cited psychosis researcher outside the USA, has supervised 72 PhDs and 12 MD Theses, and 40 of his students have become full professors. He was elected a Fellow of the Royal Society in 2010 and received a knighthood in 2011.

Description

The Brunswick has been transformed through an extensive refurbishment programme to become the premier music and arts venue in Hove. The owners are committed to providing quality, value for money and a friendly atmosphere.We believe that a pub is an essential part of any thriving community, and should be seen as a facility for the whole community. By encouraging local groups, we run a range of classes: acting, singing, painting, language, wine tasting; and have become a meeting place for a number of groups. With a large garden and a number of meeting rooms, we can offer space for most clubs, societies or social groups. If your looking for somewhere to host your book group, yoga class, dance class, debating club, and so on, give us a call, or better still, pop in. Support your local pub.

Built in the 1930’s, The Brunswick is a striking building with curved bays, turret roofs and brass crittall style windows. Much of the original paneling (the same as used in the Orient Express) has been rescued and restored, particularly in The Venue. Atmosphere and mood change as you move from the beautifully constructed sunny garden through the airy garden room to the bar (a fusion of the best of modern bar and traditional pub). Despite the high-tech sound and stage equipment, the music and arts Venue with its wood paneling, period lighting and fireplace retains a wonderfully cozy feel. Upstairs we have beautifully decorated rooms for meetings and private parties – see Function Room Hire

We offer a broad range of home cooked food every day. Accolades have included “Restaurant quality food at pub prices”; “The best Sunday Lunch in Brighton”; “As an American, I’m very critical of hamburgers – this is one of the best I’ve had anywhere.”

1 Holland Road,

Hove,

East Sussex,

England,

BN3 1JF.

01273 733984